Khuli Chana rose to fame after releasing his major successful album Motswakoriginator, which infuses both the Setswana and English languages. Motswako is a mixture of both languages and the sound and style of music originates from Mahikeng, a small town in the North West Province.
He has shared a stage with US rapper Drake, as an opening act.
Khuli Chana partnered with vodka brand Absolut as one of their ambassadors for the South Africa market.
Khuli Chana was nearly killed when members of the South African police mistook him for a criminal and proceeded to fire nine bullets at his vehicle.